随着对呼出气一氧化氮(fraction of exhaled nitric oxide,FeNO)检测认识的提高,其作为一种评估气道炎症的无创安全、简单易行的方法,受到愈来愈多学者们的关注并在肺部常见疾病的诊治中得到了广泛应用。肺炎、哮喘、慢性阻塞性肺疾病、慢性咳嗽等在全世界范围内均为高发病率的呼吸系统疾病,他们之间最大的共同点就是存在不同程度的气道炎症。本文就 FeNO 的来源及其在肺部常见疾病的检测意义和作用机制最新进展作一综述。

Detection of the fraction of exhaled nitric oxide (FeNO) is a safe, simple and easy method to assess airway inflammation noninvasively. Thus, FeNO detection has been paid more attention to diagnosis and guide treatment of pulmonary diseases. The common feature of pneumonia, asthma, chronic obstructive pulmonary disease and chronic cough is the existence of varying degrees of airway inflammation. In this review, FeNO production and its potential pathologic and physiologic role in various pulmonary diseases were discussed.

关键词: 呼出气一氧化氮; 肺炎; 哮喘; 慢性阻塞性肺疾病; 慢性咳嗽

Key words: Fraction of exhaled nitric oxide (FeNO); pneumonia; asthma; chronic obstructive pulmonary disease; chronic cough

引用本文: 沈诚, 王鑫, 李鹏飞, 车国卫. 呼出气一氧化氮在常见肺疾病中的研究进展. 中国胸心血管外科临床杂志, 2018, 25(11): 1007-1011. doi: 10.7507/1007-4848.201712061 复制

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