中国胸心血管外科临床杂志

中国胸心血管外科临床杂志

302例老年食管癌患者生存时间的影响因素分析

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目的 探索可能影响老年食管癌患者生存时间的因素。 方法 回顾性分析 2012 年 1 月至 2016 年 10 月在兰州大学第一医院、甘肃省肿瘤医院入院治疗 302 例食管癌患者的资料。采用 Kaplan-Meier 法对生存时间进行估计并进行单因素分析,生存曲线用 log-rank 进行检验,在单因素分析后对生存时间有意义的因素进行Cox 比例风险模型的多因素分析。 结果 最终纳入 302 例患者,男 231 例、女 71 例,平均年龄(66.0±6.0)岁。单因素分析显示,患者年龄、肿瘤分期、肿瘤部位、生存质量卡氏评估(KPS) 评分以及治疗方式均为预后相关因素(P<0.05)。Cox 比例风险多因素分析显示,患者年龄以及治疗方式是影响食管癌患者预后的独立因素(P<0.05)。年龄≤70 岁的患者预后优于>70 岁的患者,单纯化疗与单纯手术生存情况远优于单纯放疗。 结论 年龄、治疗方式是老年食管癌患者生存时间的独立预后因素。

Objective To explore the possible factors which influence the survival time of elderly patients with esophageal cancer. Methods We retrospectively analyzed the data of patients with esophageal cancer treated in the First Hospital of Lanzhou University, Gansu Province Tumor Hospital from January 2012 to October 2016. Kaplan-Meier method was used to estimate and analyze the single factor, survival curve with log-rank test. The Cox regression model was used for multivariate prognostic analysis. Results According to the inclusion and exclusion criteria, 302 patients were eventually collected, including 231 males and 71 females, with an average age of 66.0±6.0 years. The univariate analysis showed that age, tumor stage, tumor site, Karnosfsky performance satus (KPS) score, and treatment were prognostic factors (P<0.05). Multivariate analysis showed that the patient age and treatment were independent factors for overall survival (OS) and progress-free survival (PFS) (P<0.05). The OS and PFS of the patients with age≤70 years were better than those of the patients more than 70 years. Chemotherapy alone and surgery alone was better for survival situation than radiotherapy alone. Conclusion Age and treatment are independent prognostic factors in survival time of the elderly patients with esophageal cancer.

关键词: 老年; 食管癌; 生存时间; 影响因素; 治疗

Key words: Elderly; esophageal cancer; survival time; factors; treatment

引用本文: 刘晶晶, 刘漪珊, 朱磊, 鲁嘉驹, 师将, 薛鸿, 岳翰逊, 刘健. 302例老年食管癌患者生存时间的影响因素分析. 中国胸心血管外科临床杂志, 2019, 26(1): 83-87. doi: 10.7507/1007-4848.201804058 复制

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