中国胸心血管外科临床杂志

中国胸心血管外科临床杂志

MicroRNA-1 对急性心肌梗死诊断价值的系统评价与 Meta 分析

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目的 系统评价 microRNA-1(miRNA-1)在急性心肌梗死(acute myocardial infarction,AMI)患者诊断中的临床价值。 方法 计算机检索 PubMed、EMBASE、Cochrane Library、中国知网数据库、万方数据库、维普数据库有关 miRNA-1 诊断 AMI 的文献。采用 MetaDisc1.4 软件进行系统评价。评价指标为合并灵敏度、特异度、阳性似然比、阴性似然比、诊断比值比以及受试者工作特征曲线(Summary receiver operator characteristic curve,SROC)下面积。 结果 共纳入 12 篇文献,根据 miRNA-1 待检测人群的不同,分健康组(7 篇)和非 AMI 疾病组(5 篇)进行亚组分析,结果显示:AMI 与健康人群比较,miRNA-1 诊断 AMI 的合并灵敏度为 0.78(95%CI 0.73~0.82),特异度为 0.88(95%CI 0.83~0.91),SROC 曲线下面积为 0.911 2;AMI 与非 AMI 疾患者群比较,合并灵敏度为 0.59(95%CI:0.54~0.64),特异度为 0.74(95%CI 0.68~0.79),SROC 曲线下面积为 0.7432。 结论 miRNA-1 对诊断 AMI 具有一定的价值,可帮助鉴别 AMI 与伴随有其他系统疾病的患者,可与其它生物标志物联合诊断 AMI。

Objective To systematically evaluate the clinical value of miRNA-1 in the diagnosis of acute myocardial infarction (AMI) patients. Methods We searched PubMed, EMbase, Cochrane Library, CNKI, Wangfang, VIP, etc databases to identify literature about miRNA-1 in the diagnosis of AMI. Quality of the included literature was assesed by (quality assessment for diagnostic accuracy studies-2, QUADAS-2). The indices of pooled sensitivity (Sen), specificity (Spe), positivity likelihood ratio (PLR), negative likelihood ratio (NLR), diagnosis odds ratio (DOR), and the area under the summary receiver operating characteristic curve (SROC) were pooled using MetaDisc1.4 software. Results A total of 12 articles were included. According to the different populations of miRNA-1 to be tested, subgroup analysis of healthy people (7 articles) and non-AMI disease groups (5 articles) was conducted. The results showed that AMI compared with healthy people, the pooled Sen was 0.78 with 95%CI 0.73 to 0.82, Spe was 0.88 with 95%CI 0.83 ti 0.91 of miRNA-1 in the diagnosis of AMI, AUC of SROC curve was 0.911 2. Comparison of AMI and non-AMI patients, the pooled Sen was 0.59 with 95%CI 0.54 to 0.64, Spe was 0.74 with 95%CI 0.68 to 0.79.of miRNA-1 in the diagnosis of AMI. AUC of SROC curve was 0.7432. Conclusion miRNA-1 has a certain value in the diagnosis of AMI. It has an advantage in identifying AMI and patients with other systemic diseases, and can be combined with other biomarkers to diagnose AMI.

关键词: MicroRNA-1; 心肌梗死; 诊断; 系统评价/Meta 分析

Key words: MicroRNA-1; myocardial infarction; diagnosis; meta-analysis

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