中国胸心血管外科临床杂志

中国胸心血管外科临床杂志

正电子发射断层扫描/计算机断层扫描检测冬眠心肌的临床应用研究

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随着对缺血心肌病理生理变化的深入探讨,一部分实验研究发现许多病变重、病程长的冠状动脉粥样硬化性心脏病(冠心病)患者虽经再血管化治疗其收缩功能未能恢复的原因主要与受累区域的存活心肌相关。而存活心肌是指那些灌注缺损使其收缩功能降低的但并未发生死亡的心肌细胞,包括顿抑心肌和冬眠心肌。因而,准确评估存活心肌对这类患者的临床治疗方案的制定及预后的评估具有重要意义。正电子发射断层扫描/计算机断层扫描(positron emission computed tomography/computed tomography,PET/CT)相机可以评估冬眠心肌的存活情况并对其定量分析,从而为再血管化后心肌功能恢复的可能性、治疗方案的选择及预后的评估提供有用信息。

With the in-depth study of the pathophysiological changes of ischemic myocardium, some experimental studies have found that in many patients with coronary heart disease, severe lesions and long duration of diseases which do not recover due to revascularization, are mainly related to the viable myocardium in the affected area. Survival myocardium refers to those dysfunctional caused by perfusion defect but not dead cardiomyocytes, including stunned myocardium and hibernating myocardium. Therefore, accurate assessment of viable myocardium is important for the development of clinical treatment options and prognosis assessment of such patients. Positron emission computed tomography/computed tomography (PET/CT) camera can evaluate the survival of hibernating myocardium and quantitatively analyze it. Thus PET/CT can provide useful information for the possibility of myocardial function recovery after revascularization, treatment options and prognosis evaluation.

关键词: 正电子发射断层扫描; 计算机断层扫描; 冬眠心肌; 再血管化治疗

Key words: Positron emission computed tomography; computed tomography; hibernating myocardium; revascularization therapy

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