中国胸心血管外科临床杂志

中国胸心血管外科临床杂志

成纤维细胞生长因子 21 在动脉粥样硬化中的研究进展

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成纤维细胞生长因子 21(fibroblast growth factor 21, FGF21)是一种多效应的内分泌因子,主要在肝脏和脂肪组织中分泌,具有降脂、抗炎、抗氧化和抗动脉粥样硬化作用。近年来发现,FGF21 在心血管疾病中能够诱导保护作用,心血管疾病患者血浆中 FGF21 水平升高,可作为亚临床动脉粥样硬化的生物标志物,可作为动脉粥样硬化性心血管疾病的治疗靶点。故本文将对 FGF21 抗动脉粥样硬化作用的最新进展进行综述。

Fibroblast growth factor 21 (FGF21) is a multi-effect endocrine factor, mainly secreted in liver and adipose tissue, with the properties of lipid-lowering, anti-inflammatory, anti-oxidant and anti-atherosclerosis. Recent studies found that FGF21 can induce protective effect in cardiovascular disease, plasma FGF21 levels in patients with disease cardiovascular are elevated.These studies have suggested the use of FGF21 as a biomarker for subclinical atherosclerosis and its potential role in the treatment of established atherosclerotic cardiovascular disease. This article will review the recent advances in the anti-atherosclerosis effect of FGF21.

关键词: 成纤维细胞生长因子 21; 动脉粥样硬化; 生物标志物

Key words: Fibroblast growth factor 21; atherosclerosis; biomarker

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